Browsing by Author "Fluck, Richard"
Now showing items 1-20 of 52
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A programme to spread eGFR graph surveillance for the early identification, support and treatment of people with progressive chronic kidney disease (ASSIST-CKD): protocol for the stepped wedge implementation and evaluation of an intervention to reduce late presentation for renal replacement therapy.
(2017-04)BACKGROUND: Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community-wide ... -
A simple care bundle for use in acute kidney injury: a propensity score matched cohort study.
(2016-05)BACKGROUND: Consensus guidelines for acute kidney injury (AKI) have recommended prompt treatment including attention to fluid balance, drug dosing and avoidance of nephrotoxins. These simple measures can be incorporated ... -
Acute kidney: improving the pathway of care for patients and across healthcare.
(2015-11)PURPOSE OF REVIEW: Acute kidney injury (AKI) is common, harmful and of global concern. There is a need to understand the pathway of the management of AKI in order to identify potential areas where care can be improved, for ... -
An unusual case of severe high anion gap metabolic acidosis
(2011-04)We present a case of high anion gap metabolic acidosis with an unusual aetiology in a 75-year-old lady with hypoglycaemia, encephalopathy and relatively preserved renal function. Full toxicology and biochemical analysis ... -
Anthropomorphic measurements that include central fat distribution are more closely related with key risk factors than BMI in CKD stage 3.
(2012-04)BACKGROUND: Body Mass Index (BMI) as a marker of obesity is an established risk factor for chronic kidney disease (CKD) and cardiovascular disease (CVD). However, BMI can overestimate obesity. Anthropomorphic measurements ... -
Assessment of proteinuria in patients with chronic kidney disease stage 3: albuminuria and non-albumin proteinuria.
(2014-05)BACKGROUND AND OBJECTIVE: Proteinuria assessment is key in investigating chronic kidney disease (CKD) but uncertainty exists regarding optimal methods. Albuminuria, reflecting glomerular damage, is usually measured, but ... -
Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5-year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3.
(2017-08)OBJECTIVES: Vitamin D deficiency, elevated fibroblast growth factor 23 (FGF23) and elevated parathyroid hormone (PTH) have each been associated with increased mortality in people with chronic kidney disease (CKD). Previous ... -
Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study.
(2019-09)BACKGROUND: Acute kidney injury in hospital patients is common and associated with reduced survival and higher healthcare costs. The Tackling Acute Kidney Injury (TAKI) quality improvement project aimed to reduce mortality ... -
Chronic Kidney Disease in Primary Care: Outcomes after Five Years in a Prospective Cohort Study.
(2016-09)BACKGROUND: Chronic kidney disease (CKD) is commonly managed in primary care, but most guidelines have a secondary care perspective emphasizing the risk of end-stage kidney disease (ESKD) and need for renal replacement ... -
Clinical Practice Recommendations for the Use of Buttonhole Cannulation
(2016)Buttonhole cannulation, or buttonhole needling, is one of several methods of vascular access for dialysis patients. While this is a well-established technique, practices continue to vary across the UK. Catherine Fielding, ... -
Creation of an arteriovenous fistula is associated with significant acute local and systemic changes in microvascular function.
(2013-08)BACKGROUND: Native arteriovenous fistulae (AVF) are the vascular access of choice for haemodialysis. The consequences of AVF formation on microvascular function, locally or systemically, are unknown. METHODS: We recruited ... -
Defining the cause of death in hospitalised patients with acute kidney injury.
(2012-11)BACKGROUND: The high mortality rates that follow the onset of acute kidney injury (AKI) are well recognised. However, the mode of death in patients with AKI remains relatively under-studied, particularly in general ... -
Determinants of arterial stiffness in chronic kidney disease stage 3.
(2013-01)BACKGROUND: Early chronic kidney disease (CKD) is associated with increased cardiovascular (CV) risk but underlying mechanisms remain uncertain. Arterial stiffness (AS) is associated with increased CV risk in advanced CKD, ... -
Determinants of change in arterial stiffness over 5 years in early chronic kidney disease.
(2019-09)BACKGROUND: Arterial stiffness (AS) is an established and potentially modifiable risk factor for cardiovascular disease associated with chronic kidney disease (CKD). There have been few studies to evaluate the progression ... -
Development of a trigger tool to detect harm during haemodialysis
(2016)Haemodialysis is a widely used renal replacement therapy that is associated with multiple risks for patients. Monitoring of harm associated with haemodialysis is often limited to reporting of critical incidents, which is ... -
Effect of weekend admission on mortality associated with severe acute kidney injury in England: A propensity score matched, population-based study
(2017-10)Background Increased in-hospital mortality associated with weekend admission has been reported for many acute conditions, but no study has investigated “weekend effect” for acute kidney injury requiring dialysis (AKI-D). ... -
Effects of arteriovenous fistula formation on arterial stiffness and cardiovascular performance and function.
(2011-10)s.korsheed@googlemail.com BACKGROUND: Native arteriovenous fistula (AVF) is the vascular access of choice and its use cf. catheters is associated with sustained reduction in mortality. This may be due to factors beyond ... -
Epidemiology of Staphylococcus aureus bacteraemia amongst patients receiving dialysis for established renal failure in England in 2009 to 2011: a joint report from the Health Protection Agency and the UK Renal Registry.
(2012-09)INTRODUCTION: Infection remains one of the leading causes of death in patients with end-stage renal failure (ESRF) receiving dialysis. Since April 2007, all centres providing renal replacement therapy in England have been ... -
Establishing a Core Outcome Measure for Fatigue in Patients on Hemodialysis: A Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) Consensus Workshop Report.
(2018-03)Fatigue is one of the most highly prioritized outcomes for patients and clinicians, but remains infrequently and inconsistently reported across trials in hemodialysis. We convened an international Standardized Outcomes in ... -
Gentamicin-associated acute kidney injury
(2009-12)BACKGROUND: The incidence of gentamicin-associated acute kidney injury (AKI) as defined by the RIFLE criteria is unknown. AIM AND DESIGN: We performed a retrospective observational study to examine this and the predictive ...
