Browsing by Subject "Pain"
Now showing items 1-20 of 22
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Baseline self-report 'central mechanisms' trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort
(2019-12)Objectives: We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain in the Community cohort. Method: 1471 participants reported knee pain ... -
A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.
(2015-01-20)INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment ... -
Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.
(McWilliams, D. F. et al. (2016) ‘Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data’, Arthritis Research & Therapy, 18, p. 295., 2016-12-13)ACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ... -
Discrete Trajectories of Resolving and Persistent Pain in People With Rheumatoid Arthritis Despite Undergoing Treatment for Inflammation: Results From Three UK Cohorts.
(2019-01-15)Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesized that discrete RA subgroups might ... -
Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.
(2019-11)Background: RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and ... -
Factors predicting pain and early discontinuation of tumour necrosis factor-alpha-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.
(2016-08-12)BACKGROUND: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of ... -
The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.
(2019-03)Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic ... -
Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis
(2016-04-28)Background: The 28-joint DAS with ESR (DAS28-ESR) is used as a measure of inflammatory disease activity in RA. However, pain and non-inflammatory mechanisms (e.g. central sensitisation) might confound the DAS28 by modulating ... -
Investigating musculoskeletal health and wellbeing; a cohort study protocol.
(2020-03)Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal ... -
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.
(2019-04)OBJECTIVE: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium ... -
Pain assessment in people with dementia
(Elsevier, 2017-09)This chapter is concerned with the recognition of pain in people with dementia and aims to provide a balanced presentation of the evidence available. This chapter will examine issues relating to the British national ... -
Pain evaluation in the preterm
(2014-10)Assessment of pain is a challenge in neonatal setting. Visual, behavioural and physiological pain scales are not always reliable in premature infants. Few studies with limited sample size have been published on the reliability ... -
Pain mechanisms in rheumatoid arthritis
(2017-09)Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, ... -
Pain sensitivity in healthy volunteers and people with knee Osteoarthritis
(2012)Background: Osteoarthritis (OA) is the most common form of arthritis worldwide and a major cause of pain and disability, and yet underlying mechanisms of OA pain are not entirely understood. There is compelling evidence ... -
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
(2019-03-18)Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a ... -
Predictors of painkiller dependence among people with pain in the general population
(2014)Objectives: Self-medication with painkillers is widespread and increasing, and evidence about influences on painkiller dependence is needed to inform efforts to prevent and treat problem painkiller use. Design: Online ... -
Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis.
(2019-09)Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse clinical outcomes, but the ability of quantitative sensory testing (QST), an index of sensitisation, to predict outcomes in chronic ... -
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
(2012-10-20)Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, ... -
A randomised controlled trial on the effectiveness of a lateral glide cervical spine mobilisation on cervicobrachial (neck and arm) pain
(2015-05)Cervicobrachial (neck and arm) pain is a painful condition which, when chronic, leads to high levels of disability. Small-scale, short-term (<2 months follow-up) studies have identified that lateral glide mobilisation ... -
Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.
(2018-06)This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n = 420) in the Knee Pain and related health In the Community (KPIC) baseline survey ...
