Browsing University Hospitals of Derby and Burton NHS Foundation Trust by Author "Jefferies, Helen"
Now showing items 1-11 of 11
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Circulating endotoxaemia and frequent haemodialysis schedules
(2014-11)BACKGROUND/AIMS: Endotoxaemia, a driver of systemic inflammation, appears to be driven by dialysis-induced circulatory stress in haemodialysis (HD) patients. More frequent HD regimens are associated with lower ultrafiltration ... -
Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease.
(2011-01)BACKGROUND AND OBJECTIVES: Translocated endotoxin derived from intestinal bacteria has a wide range of adverse effects on cardiovascular (CV) structure and function, driving systemic inflammation, atherosclerosis and ... -
Elevated serum free pregnancy-associated plasma protein-A independently predicts mortality in haemodialysis patients but is not associated with recurrent haemodialysis-induced ischaemic myocardial injury.
(2015-03)BACKGROUND/AIMS: Pregnancy-associated plasma protein-A (PAPP-A) is a putative marker of atheroma instability and ischaemic myocardial stress prior to necrosis. Total PAPP-A (tPAPP-A) levels in acute coronary syndromes ... -
Frequent hemodialysis schedules are associated with reduced levels of dialysis-induced cardiac injury (myocardial stunning).
(2011-06)BACKGROUND AND OBJECTIVES: Recurrent hemodialysis (HD)-induced ischemic cardiac injury (myocardial stunning) is common and associated with high ultrafiltration (UF) requirements, intradialytic hypotension, long-term loss ... -
High magnesium dialysate does not improve intradialytic hemodynamics or abrogate myocardial stunning.
(2020-08)BACKGROUND: Hemodialysis (HD) induces myocardial stunning and is associated with adverse cardiovascular outcomes. Intradialytic hypotension is a modifiable determinant of myocardial stunning. Magnesium (Mg) is reported to ... -
Individualised dialysate temperature improves intradialytic haemodynamics and abrogates haemodialysis-induced myocardial stunning, without compromising tolerability.
(2011-01)BACKGROUND/AIMS: Haemodialysis-induced myocardial stunning is associated with intradialytic hypotension, increased likelihood of cardiovascular events and death. Dialysis at 35°C reduces stunning, but adverse thermal ... -
Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients.
(2016-11)Introduction Repetitive dialysis-induced cardiac injury is associated with elevated troponin levels, inflammation, and longitudinal reduction in cardiac function. Pathogenic autoantibodies to cardiac troponins (cTnAAb) ... -
Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients.
(2016-11)Introduction Repetitive dialysis-induced cardiac injury is associated with elevated troponin levels, inflammation, and longitudinal reduction in cardiac function. Pathogenic autoantibodies to cardiac troponins (cTnAAb) ... -
The impact of hemodialysis on segmental and global longitudinal myocardial strain.
(2014-11)Strain analysis derived from the analysis of speckle tracked imaging echocardiography can be used to examine ventricular contractile functions. In this study, we examined the relationship of hemodialysis (HD)-induced ... -
Tissue-advanced glycation end product concentration in dialysis patients.
(2010-01)BACKGROUND AND OBJECTIVES: Tissue-advanced glycation end products (AGE) are a measure of cumulative metabolic stress. Assessment of tissue AGE by skin autofluoresence (AF) correlates well with cardiovascular outcomes in ... -
Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients.
(2012-08)BACKGROUND AND OBJECTIVES: Circulating troponin T levels are frequently elevated in patients undergoing long-term dialysis. The pathophysiology underlying these elevations is controversial. DESIGN, SETTING, PARTICIPANTS, ...