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Now showing items 11-20 of 27
A literature review: The role of plakoglobin as a biomarker to determine the invasive potential of ductal carcinoma in situ
(2018-01)
DCIS is a heterogeneous disease exhibiting varying degrees of aggressiveness; approximately 40% of DCIS will progress into invasive cancer. Currently, no molecular marker is identified that can reliably predict the invasive ...
Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study.
(2018-02)
PURPOSE: Wire localization has several disadvantages, notably wire migration and difficulty scheduling the procedure close to surgery. Radioactive seed localization overcomes these disadvantages, but implementation is ...
Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).
(2019-12)
PURPOSE: The STAKT study examined short-term exposure (4.5 days) to oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly ...
Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?
(2017-09)
BACKGROUND: Clinicians use clinical and pathological parameters, such as tumour size, grade and nodal status, to make decisions on adjuvant treatments for breast cancer. However, therapeutic decisions based on these features ...
Evaluation of patient-centred communication in breast clinic; how are we doing and what we need to improve?
(2018-01)
Effective patient-centred communication is vital in rapid access breast clinics. Health care professionals (HCP) need to demonstrate focused active listening, express empathy, and understand the patient's perspective ...
The effects of a home-based physical activity intervention on cardiorespiratory fitness in breast cancer survivors; a randomised controlled trial.
(2018-05)
The aim of this current randomised controlled trial was to evaluate the effects of a home-based physical activity (PA) intervention on cardiorespiratory fitness in breast cancer survivors. Thirty-two post-adjuvant therapy ...
Concordance between the HCPs' and patient's perception of the efficiency of the clinical consultation in breast clinic, scope for improvement
(2018-01)
The psychological stress of patients attending breast clinic can be managed by effective communication. Healthcare professionals (HCPs) in breast clinics need outstandingly professional patient-centred communication skills ...
Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells.
(2017-02)
Bardoxolone-methyl (BAR) is reported to have anti-inflammatory, anti-proliferative and anti-fibrotic effects. BAR activates Nrf2 and may ameliorate oxidative stress through induction of antioxidant genes. However, off-target ...
NHS Breast Screening multidisciplinary working group guidelines for the diagnosis and management of breast lesions of uncertain malignant potential on core biopsy (B3 lesions).
(2018-05)
Needle core biopsy is considered the histological diagnostic method of choice for screen-detected breast lesions. Although the majority are definitively diagnosed as normal, benign, or malignant, approximately 7% are ...