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Efficacy of metformin in pregnant obese women: a randomised controlled trial.
(2015-01-14)
INTRODUCTION: Increasing evidence suggests obesity has its origins prior to birth. There is clear correlation between maternal obesity, high birthweight and offspring risk of obesity in later life. It is also clear that ...
Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial.
(2020-09-28)
Background: The optimal timing of radiotherapy after radical prostatectomy for prostate cancer is uncertain. We aimed to compare the efficacy and safety of adjuvant radiotherapy versus an observation policy with salvage ...
Prognostic accuracy of emergency department triage tools for children with suspected COVID-19: The PRIEST observational cohort study.
(2020-09)
Objectives: Emergency department clinicians can use triage tools to predict adverse outcome and support management decisions for children presenting with suspected COVID-19. We aimed to estimate the accuracy of triage tools ...
Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort.
(2016-07-05)
OBJECTIVES: To evaluate the implementation of four high evidence practices for the care of very preterm infants to assess their use and impact in routine clinical practice and whether they constitute a driver for reducing ...
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
(2015-07)
BACKGROUND: Maternal obesity is associated with increased birthweight, and obesity and premature mortality in adult offspring. The mechanism by which maternal obesity leads to these outcomes is not well understood, but ...
6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial.
(2019-06-06)
BACKGROUND: Adjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter treatment could provide similar efficacy while ...
Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
(2020-04)
Background: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence ...
. Evaluation of the Implementation of the Saving Babies’ Lives Care Bundle in early adopter NHS Trusts in England.
(Maternal and Fetal Health Research Centre, University of Manchester., 2018-11)
This report presents the findings from the Saving Babies Lives Project Impact and Results Evaluation (SPiRE) conducted by the Tommy's Stillbirth Research Centre at the University of Manchester commissioned by NHS England ...
Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: The PRIEST observational cohort study.
(2020-09)
Objectives: The World Health Organisation (WHO) and National Institute for Health and Care Excellence (NICE) recommend various triage tools to assist decision-making for patients with suspected COVID-19. We aimed to estimate ...
Introducing artificial intelligence tools into clinical and non-clinical workflows, Evidence from the NHS Breast Screening Programme of staff and general population perceptions of and trust in the use of AI in this context and the implications for further testing and implementation.
(https://hsruk.org/conference-2020/presentations/understanding-service-use, 2020-06)
Background: The East Midlands Radiology Consortium (EMRAD) is a partnership of seven NHS trusts spread over 11 hospitals, covering more than five million patients in the East Midlands of England. In 2018, EMRAD formed a ...