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Efficacy of metformin in pregnant obese women: a randomised controlled trial.
(2015-01-14)
INTRODUCTION: Increasing evidence suggests obesity has its origins prior to birth. There is clear correlation between maternal obesity, high birthweight and offspring risk of obesity in later life. It is also clear that ...
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
(2015-07)
BACKGROUND: Maternal obesity is associated with increased birthweight, and obesity and premature mortality in adult offspring. The mechanism by which maternal obesity leads to these outcomes is not well understood, but ...
Shared genetic etiology of obesity-related traits and Barrett's esophagus/adenocarcinoma: Insights from genome-wide association studies.
(2020-02)
Background: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barrett's esophagus (BE). Research suggests that individuals with high genetic risk to obesity have a higher BE/EA risk. To ...
Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans.
(2020-01-16)
Objective: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated ...
Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans
(2016-09)
Objectives: To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters ...
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
(2020-10)
Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established.
Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a ...
How can referrals of patients who are obese to the local exercise referral scheme be increased? A UK based primary care quality improvement study.
(2020-06)
Background: Obesity is classified as a body mass index (BMI) >30kg/m 2 and contributes to poor health outcomes in the UK. In 2017-18, obesity resulted in 711,000 hospital admissions. The National Institute for Health and ...