Now showing items 1-10 of 35
Comorbidity and its relevance on general hospital based mortality in major depressive disorder: A naturalistic 12-year follow-up in general hospital admissions
Major depressive disorder (MDD) is associated with physical comorbidity, but the risk factors of general hospital-based mortality are unclear. Consequently, we investigated whether the burden of comorbidity and its relevance ...
Suicidal events due to overdose and medical comorbidities in psychiatric disorders of ICD-10 classes F1-F4: A comparative overview of five studies in general hospital admissions
Introduction General hospital-based studies may help towards improving the treatment of psychiatric disorders. Objectives and aims Based on five representative studies in general hospital admissions, we will represent a ...
Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease
Early-onset Alzheimer's disease (EOAD) can be familial (FAD) or sporadic EOAD (sEOAD); both have a disease onset <65 years of age. A total of 451 sEOAD samples were screened for known causative mutations in exons 16 and ...
Physical comorbidity and consequences for mortality and treatment
Introduction Ageing is related to an increase rate of physical comorbidity. However, the interaction between physical comorbidity and the development of depression in the elderly is not yet clear. Depression may be the ...
Alcohol dependence and physical comorbidity: Increased prevalence but reduced relevance of individual comorbidities for hospital-based mortality during a 12.5-year observation period in general hospital admissions in urban North-West England.
Alcohol dependence (AD) is associated with an increase in physical comorbidities. The effects of these diseases on general hospital-based mortality are unclear. Consequently, we conducted a mortality study in which we ...
Medical comorbidity related risk factors for hospital-based mortality in psychiatric disorders of ICD-10 classes F1-F4: A comparative overview of five studies in general hospital admissions
Introduction Up to 60% of the non-suicide related premature mortality of individuals with major psychiatric disorders is said to be mainly due to medical diseases. Objectives and aims Based on five representative studies ...
Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.
Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial "hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, ...
Blood type gene locus has no influence on ACE association with Alzheimer's disease
The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (. ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only ...
Anxiety disorders and physical comorbidity: Increased prevalence but reduced relevance of specific risk-factors for hospital-based mortality during a 12.5-year observation period in general hospital admissions.
Introduction. Anxiety disorders (AD) are associated with an increase of physical comorbidity but the effects of these diseases on hospital-based mortality are unclear. Objectives and aims. To investigate whether the burden ...
The burden of cardiovascular disease amongst psychiatric patients