Now showing items 1-10 of 29
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ...
Estimation and partitioning of polygenic variation captured by common snps for alzheimer's disease, multiple sclerosis and endometriosis.
Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for ...
TREM2 variants in Alzheimer's disease
Background: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. ...
The efficacy of agomelatine in elderly patients with recurrent major depressive disorder: A placebo-controlled study
Objective: The present placebo-controlled study evaluated the efficacy, tolerability, and safety of 8-week treatment with agomelatine (25-50 mg/d by mouth) in elderly patients with major depressive disorder (MDD). Method: ...
How to use... an autism assessment tool.
Autism is a neurodevelopmental condition affecting three main areas: social communication, social interaction and restricted patterns of behaviour, interests and activities. The Diagnostic and Statistical Manual of Mental ...
Essentials of Physical Health in Psychiatry
No Abstract. This is a book review
The Italian version of the Social Comparison Rating Scale and the Submissive Behaviour Scale: Reliability and validity in a sample of adolescents
Social rank theory argues that social comparison and submissive behaviour are mechanisms by which humans and animals form themselves into social ranks. Design: this study assesses the psychometric properties of Italian ...
Alzheimer's disease and co-morbidity: Increased prevalence and possible risk factors of excess mortality in a naturalistic 7-year follow-up
Background. - Subjects with late-onset Alzheimer's disease (AD) have to be sufficiently healthy to live long enough to experience and to be diagnosed with dementia in later life. In contrast, neurodegeneration and cognitive ...
Risk factors associated with repetition of self-harm in black and minority ethnic (BME) groups: A multi-centre cohort study.
Background: Little information is available to inform clinical assessments on risk of self-harm repetition in ethnic minority groups. Methods: In a prospective cohort study, using data collected from six hospitals in England ...
Suicide and self-injury: a recovery based approach.
This article describes a new training programme for clinical staff working with those who present with self-injurious and suicidal behaviour using a recovery focused approach to promote safety and manage risk. The two-day ...