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Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease
Early-onset Alzheimer's disease (EOAD) can be familial (FAD) or sporadic EOAD (sEOAD); both have a disease onset <65 years of age. A total of 451 sEOAD samples were screened for known causative mutations in exons 16 and ...
Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.
Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial "hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, ...
Blood type gene locus has no influence on ACE association with Alzheimer's disease
The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (. ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only ...
Co-morbidity and mortality in alzheimer's disease.
Introduction. The interface of physical and mental health and its relevance for diagnosis and therapy in Alzheimer's disease (AD) is clinically relevant for efforts that aim on the reduction of avoidable mortality. Objectives ...
PLD3 in non-familial Alzheimer's disease.
No abstract found
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
Genome-wide association studies (GWAS) have identified several risk variants for late-onset Alzheimer's disease (LOAD). These common variants have replicable but small effects on LOAD risk and generally do not have obvious ...
Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ...
TREM2 variants in Alzheimer's disease
Background: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. ...
Estimation and partitioning of polygenic variation captured by common snps for alzheimer's disease, multiple sclerosis and endometriosis.
Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for ...
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ...