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Adjunctive antipsychotic in the treatment of body dysmorphic disorder - A retrospective naturalistic case note study
(2015)
Objectives: A retrospective naturalistic case note study to determine the frequency, co-morbidity and treatment-response of body dysmorphic disorder (BDD). Methods: Records from 280 patients attending a highly specialised ...
Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial
(2016)
Negative symptoms of schizophrenia represent deficiencies in emotional responsiveness, motivation, socialisation, speech and movement. When persistent, they are held to account for much of the poor functional outcomes ...
Sustained efficacy and safety of agomelatine versus placebo over 24 weeks in elderly out-patients suffering from major depressive disorder
(2014)
With an increasingly ageing population, there is a growing need to develop novel ways to treat depression in the elderly. Few published placebo-controlled study results in elderly depressed patients reached a clinical ...
Effectiveness comparison of antipsychotics used in first-episode psychosis: A naturalistic cohort study
(2014)
Introduction: Several studies have explored comparative effectiveness of first prescribed antipsychotics for FEP using time to treatment discontinuation as a proxy measure. Consistent differences are not demonstrated. We ...
Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial
(2016)
Negative symptoms of schizophrenia represent deficiencies in emotional responsiveness, motivation, socialisation, speech and movement. When persistent, they are held to account for much of the poor functional outcomes ...
Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial
(2017)
Background The use of electroconvulsive therapy (ECT) is limited by concerns about its cognitive adverse effects. Preliminary evidence suggests that administering the glutamate antagonist ketamine with ECT might alleviate ...
Long-term antidepressant treatment for negative symptoms in schizophrenia: The actions study
(2017)
Background: The negative symptoms of schizophrenia represent defcien-cies in emotional responsiveness, motivation and socialization that tend to be persistent despite standard antipsychotic treatment. Two sub-domains of ...
The clinical effectiveness and cost-effectiveness of lamotrigine in borderline personality disorder: A randomized placebo-controlled trial
(2018)
Objective: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. Method: This was a multicenter, double-blind, placebo-controlled ...
Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal toxicity associated with self-poisoning
(2018)
Background: Bipolar and other psychiatric disorders are associated with considerably increased risk of suicidal behaviour, which may include self-poisoning with medication used to treat the disorder. Therefore, choice of ...
Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT
(2018)
BACKGROUND: Very late-onset (aged & greater than 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. ...