Now showing items 1-10 of 12
Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.
Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial "hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, ...
Blood type gene locus has no influence on ACE association with Alzheimer's disease
The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (. ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only ...
PLD3 in non-familial Alzheimer's disease.
No abstract found
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
Genome-wide association studies (GWAS) have identified several risk variants for late-onset Alzheimer's disease (LOAD). These common variants have replicable but small effects on LOAD risk and generally do not have obvious ...
Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ...
TREM2 variants in Alzheimer's disease
Background: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. ...
Estimation and partitioning of polygenic variation captured by common snps for alzheimer's disease, multiple sclerosis and endometriosis.
Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for ...
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ...
Role of PLD3 rare variants in european non-familial Alzheimer's disease
Interest in the role of rare genetic variants in the etiology of complex diseases such as Alzheimer's disease (AD) is increasing. In January 2014, Cruchaga et al. provided evidence supporting the role of rare variants in ...
Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol ...