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The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (. ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only ...

Interest in the role of rare genetic variants in the etiology of complex diseases such as Alzheimer's disease (AD) is increasing. In January 2014, Cruchaga et al. provided evidence supporting the role of rare variants in ...

Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol ...

We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ...

Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for ...

Background: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. ...

Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD). However, although the main effects of aromatase variants suggest a ...

GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ...

Background: Alzheimer's disease (AD) is a severe multifactorial disorder and the individual genetic predisposition plays a decisive role in its etiology. While genome-wide association studies have been successful in ...