Now showing items 11-20 of 29
Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ...
TREM2 variants in Alzheimer's disease
Background: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. ...
Compassion is the key
Estimation and partitioning of polygenic variation captured by common snps for alzheimer's disease, multiple sclerosis and endometriosis.
Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for ...
Self-harm is common in adolescents in England
Question: What are the epidemiology and characteristics of self-harm in adolescents in England? Population: In total, 5205 children and adolescents aged up to 18 presenting with self-harm to general hospital emergency ...
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ...
How to use... an autism assessment tool.
Autism is a neurodevelopmental condition affecting three main areas: social communication, social interaction and restricted patterns of behaviour, interests and activities. The Diagnostic and Statistical Manual of Mental ...
Screening for dementia in primary care.
The literature on the diagnosis of dementia in primary care has been summarised in a meta-analysis that indicated that GPs recognise three in four patients with dementia using clinical judgment alone whilst highlighting ...
Alzheimer's disease and co-morbidity: Increased prevalence and possible risk factors of excess mortality in a naturalistic 7-year follow-up
Background. - Subjects with late-onset Alzheimer's disease (AD) have to be sufficiently healthy to live long enough to experience and to be diagnosed with dementia in later life. In contrast, neurodegeneration and cognitive ...
Entrapment and Defeat Perceptions in Depressive Symptomatology: Through an Evolutionary Approach.
The social rank and arrested defenses model for mood disorders bridges between animal and human models of psychopathology. There is increasing evidence that depression is associated with subordinated and loss of social ...