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dc.contributor.authorTaal, Maarten
dc.date.accessioned2019-10-16T11:30:57Z
dc.date.available2019-10-16T11:30:57Z
dc.date.issued2019-11
dc.identifier.citationCurr Opin Nephrol Hypertens. 2019 Nov;28(6):507-512. doi: 10.1097/MNH.0000000000000549.en
dc.identifier.urihttps://orda.derbyhospitals.nhs.uk/handle/123456789/2141
dc.descriptionAuthor(s) Pre Print Version. 12 Month Embargo on Posten
dc.description.abstractPURPOSE OF REVIEW: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of AGE formation and reviews published literature on SAF as a biomarker and risk factor across the spectrum of kidney disease. RECENT FINDINGS: SAF is elevated in adults and children on dialysis. Higher SAF is an independent risk factor for cardiovascular and all-cause mortality in persons receiving haemodialysis and for all-cause mortality in persons performing peritoneal dialysis, though the increase in discrimination when SAF was added to traditional risk factors was modest. In less advanced chronic kidney disease, higher SAF predicts all-cause mortality and progression. SAF is elevated in renal transplant recipients, but to a lesser extent than in dialysis patients. In one study, higher SAF predicted graft loss and mortality. SAF has been reported to be increased in patients with acute kidney injury. SUMMARY: A growing body of evidence attests that SAF, a marker of AGE accumulation, is a risk factor for mortality and kidney function decline in multiple types of kidney disease. Further studies are warranted to evaluate interventions to reduce SAF and the impact on clinical outcomes.en
dc.language.isoenen
dc.subjectSkin Autofluorescenceen
dc.subjectBiomarkersen
dc.subjectKidney Diseaseen
dc.titleSkin autofluorescence: an emerging biomarker in persons with kidney disease.en
dc.typeArticleen


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