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dc.contributor.authorFernando, Devaka
dc.date.accessioned2020-06-24T16:18:02Z
dc.date.available2020-06-24T16:18:02Z
dc.date.issued2020-01-16
dc.identifier.citationIllangasekera, Y. A. et al. (2020) ‘Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans’, BMC Research Notes, 13(1), p. 34. doi: 10.1186/s13104-020-4898-4.en
dc.identifier.otherPMC6966896
dc.identifier.urihttps://orda.derbyhospitals.nhs.uk/handle/123456789/2217
dc.descriptionOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International Licenseen
dc.description.abstractObjective: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated with obesity measures in various ethnicities. We investigated the association of the Q223R polymorphism with obesity related anthropometric measures and biochemical parameters fasting blood glucose and lipid profile in a sample of 530 Sri Lankan adult subjects (age 18-70 years) representing both urban and rural areas of residence. Results: The LEPR Q223R variant G allele frequency was 0.54. The polymorphism was associated with body mass index (p = 0.04) and waist circumference (p = 0.02) measures in overweight and obese (BMI ≥ 25 kgm -2 ) subjects with the variant allele conferring a greater risk of adiposity. Residency in urban areas eliminated the protective effect of the non-risk genotype (AA) in the development of obesity.en
dc.description.sponsorshipPDN/0-Med/N4 Ministry of Higher Education, Sri Lankaen
dc.language.isoenen
dc.subjectObesityen
dc.subjectPolymorphismen
dc.subjectReceptors, Leptinen
dc.subjectGeneticsen
dc.subjectSri Lankaen
dc.titleAssociation of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans.en
dc.typeArticleen


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