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Now showing items 1-20 of 1562
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12 Years data on resistance pattern of uropathogens
(2014-10)Urinary tract infection (UTI) is a common bacterial infection in infants and children. Traditionally, Trimethoprim has been the first line antibiotic of choice for the treatment of Coliform UTI. Empirical antibiotic treatment ... -
13-Valent vaccine serotype pneumococcal community acquired pneumonia in adults in high clinical risk groups.
(2018-02)There is debate regarding the value of vaccinating adults with the 13-valent pneumococcal conjugate vaccine (PCV-13). This analysis was conducted to investigate the risk of PCV-13 serotype community acquired pneumonia (CAP) ... -
A 40-year-old woman ‘off legs’
(2013-10)We present the case of a 40-year-old woman with progressive lower-limb weakness resulting in an inability to mobilise independently. This was associated with a degree of confusion and shortness of breath on exertion. This ... -
6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial.
(2019-06)BACKGROUND: Adjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter treatment could provide similar efficacy while ... -
6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial.
(2019-06-06)BACKGROUND: Adjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter treatment could provide similar efficacy while ... -
A 31-day time to surgery compliant exercise training programme improves aerobic health in the elderly.
(2016-06)BACKGROUND: Over 41,000 people were diagnosed with colorectal cancer (CRC) in the UK in 2011. The incidence of CRC increases with age. Many elderly patients undergo surgery for CRC, the only curative treatment. Such patients ... -
A comparison between one-stage and two-stage procedures for the creation of brachiobasilic arteriovenous fistulas.
(2015-06)INTRODUCTION: Vascular access is essential to end-stage renal failure patients requiring haemodialysis. Many patients require multiple fistula formation attempts in order to gain good access, making secondary and tertiary ... -
A comparison of nonoperative vs. Endobutton repair of distal biceps ruptures
(2016)BACKGROUND: The aim of this study was to compare the outcome of patients who have undergone distal biceps tendon repair by a single-incision Endobutton fixation technique with the results of another cohort of patients who ... -
A comparison of the natural history and outcome of treatment for Asian and non-Asian hepatitis C-infected patients.
(2011-07)Ethnicity is an important host variable, but its impact on disease progression and response to therapy in Hepatitis C infection is unclear. Here we compare the natural history and outcome of therapy in white and Asian ... -
A diagnostic head and neck fine needle aspiration service can be provided using liquid-based cytology only.
(2016-06)OBJECTIVE: Liquid-based cytology (LBC) has been used for non gynaecological specimens since its introduction into routine use in cervical cytology in the mid-1990s. There are still relatively few large studies comparing ... -
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
(2013)We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ... -
A Multiple Timepoint Pre-post Evaluation of a 'Sexual Respect' DVD to Improve Competence in Discussing Sex with Patients with Disability.
(2015)Sexual problems are common after chronic illnesses and disability, yet research indicates that this is a neglected area in healthcare services. Evaluation studies provide evidence of the effectiveness of education in ... -
A pilot feasibility study exploring the practising of compassionate imagery exercises in a nonclinical population
(2016)This study assessed the acceptability of practising compassionate imagery as an online task without clinician support. Participants completed questionnaires at baseline, after, and 6 months of follow-up. Participants engaged ... -
A preliminary randomized controlled study to determine the application frequency of a new lymphoedema bandaging system.
(2012-03)BACKGROUND: Bandaging plays an important role in the treatment of lymphoedema. OBJECTIVE: To investigate efficacy and safety of the 3M™ Coban™ 2 compression system (Coban 2 system) with different application frequencies ... -
A programme to spread eGFR graph surveillance for the early identification, support and treatment of people with progressive chronic kidney disease (ASSIST-CKD): protocol for the stepped wedge implementation and evaluation of an intervention to reduce late presentation for renal replacement therapy.
(2017-04)BACKGROUND: Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community-wide ... -
A prospective study of adverse drug reactions to antiepileptic drugs in children.
(2015-06)Antiepileptic drugs (AEDs) and to prospectively evaluate the effect of AEDs on behaviour. SETTING: A single centre prospective observational study. PARTICIPANTS: Children (<18 years old) receiving one or more AEDs for ... -
A proven alternative to compression bandaging
(2017-04) -
A questionnaire survey comparing the educational priorities of patients and medical students in the management of multiple sclerosis.
(2014-12)OBJECTIVE: To compare the educational priorities patients and students raise concerning the management of multiple sclerosis (MS). DESIGN/SETTING: A single-centre comparative questionnaire survey conducted in a foundation ...
